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KMID : 1140120070120020075
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Cancer Prevention Research
2007 Volume.12 No. 2 p.75 ~ p.78
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Association between the CYP2A6 Genetic Polymorphism and Smoking or Sister Chromatid Exchanges
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Yang Mi-Hi
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Abstract
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The genetic polymorphism of cytochrome P450 (CYP) 2A6 has been emphasized to induce variations in smoking behavior, and in susceptibility to smoking-related cancer. However, there were a few studies concerning the CYP2A6 polymorphism in Korean populations. Therefore, focusing on presence of the CYP2A6 null allele (CYP2A6*4), I studied distribution of the CYP2A6 polymorphism in a Korean population (n=100) and its effects on sister chromatid exchange (SCE), a responsive biomarker for smoking or carcinogens. As results, the subjects who had the homozygous mutant type, the CYP2A6*4/*4,
occupied 5.4% of the all subjects and most of them belonged to nonsmokers. However, the CYP2A6 polymorphism was not associated with the SCE levels (p=0.25), which were related to sex, smoking, and alcohol drinking. Therefore, presence of the CYP2A6 null allele may influence smoking behavior, however, it may be not involved in SCE-medicated cancer process. (Cancer Prev Res 12, 75-78, 2007)
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KEYWORD
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CYP2A6, Genetic polymorphism, Smoking, SCE
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